Work design refers to the study, creation, and modification of the composition, content, structure of tasks and roles and the environment in which they are performed. A measure with evidence of validity is necessary to understand the impact of work design on people and organizations. To obtain such evidence in the Brazilian context, we conducted two studies to adapt an instrument developed in a different cultural context. Study 1 performed an exploratory factor analysis assessing the latent structure of the Work Design Questionnaire (N = 1,017). Study 2 confirmed the fit of the structure found (N = 1,224) and the robustness of the taxonomy investigated. The structure identified in the analysis corroborated one of the originally proposed models, including 18 subcategories and 71 items presenting adequate psychometric indexes.